abstract：:Ras proteins play a critical role in controlling normal cellular growth and, when activated by mutation, in causing malignant transformation. Regulation of p21ras is achieved by GTPase activating proteins, which control the rate of hydrolysis of GTP to GDP, and also by GDP dissociation stimulators, which catalyze the ...

journal_title：Current opinion in genetics & development

authors： Downward J

更新日期：1992-02-01 00:00:00

abstract：:Ten years after the initial description of acquired immune deficiency syndrome, its causative agent, the human immunodeficiency virus, remains the subject of intense scientific interest. Recent research has focused on the detailed analysis of the molecular principles governing gene expression and virion formation and ...

journal_title：Current opinion in genetics & development

authors： Kräusslich HG

更新日期：1992-02-01 00:00:00

abstract：:During the past year, significant advances have been made in understanding the functions of the oncoproteins, E6 and E7, of human papillomaviruses that are associated with malignant genital tumors. In addition, important new information is now available on the responses of both the keratinocyte and of the individual f...

journal_title：Current opinion in genetics & development

authors： Gissmann L

更新日期：1992-02-01 00:00:00

abstract：:SINEs with internal promoters for RNA polymerase III are ubiquitous in the genomes of the animal kingdom, including invertebrates. Although the human Alu family, and related families, originates from 7SL RNA, all other SINEs originate from tRNA. SINEs have been amplified many times, altered in genomic organization and...

journal_title：Current opinion in genetics & development

authors： Okada N

更新日期：1991-12-01 00:00:00

abstract：:The recent discovery of self-splicing introns in cyanobacteria has given renewed interest to the question of whether introns may have been present in the ancestor of all living things. The properties of introns in genes of bacteria and bacteriophages are discussed in the context of their possible origin and biological...

journal_title：Current opinion in genetics & development

authors： Shub DA

更新日期：1991-12-01 00:00:00

abstract：:Filamentous cyanobacteria, the only prokaryotes that form linear patterns of differentiated cells, can be genetically manipulated by the conjugative transfer of plasmids from Escherichia coli. It has become possible to determine the cellular localization of genetic transcription, including transcription of development...

journal_title：Current opinion in genetics & development

authors： Wolk CP

更新日期：1991-10-01 00:00:00

abstract：:The ciliated protozoa undergo an extensive genome reorganization during the course of forming a transcriptionally active macronucleus. The process includes numerous chromosome fragmentation and DNA breakage and rejoining events. Recent work indicates that transposable elements play a role in the process. ...

journal_title：Current opinion in genetics & development

authors： Klobutcher LA,Jahn CL

更新日期：1991-10-01 00:00:00

abstract：:In recent years, the classical approaches of experimental embryology have been used in combination with more modern techniques to investigate aspects of neurogenesis. This combination has advanced our knowledge of several areas of neuronal development, including the lineages of neuronal precursors, the segmentation of...

journal_title：Current opinion in genetics & development

authors： Fraser SE

更新日期：1991-08-01 00:00:00

abstract：:The introduction of the genome database to the human gene mapping community in September 1990 heralded the advent of a new generation of databases to serve the needs of the human genome initiative over the coming years. The databases will act as a fulcrum around which the activities of the human genome initiative can ...

journal_title：Current opinion in genetics & development

authors： Pearson PL

更新日期：1991-06-01 00:00:00

abstract：:The cloning of large DNAs as yeast artificial chromosomes (YACs) holds the promise of greatly expanding the scope of physical genomic mapping. Recent improvements in YAC clone libraries and their screening, as well as in the analysis of YAC-cloned DNA, are beginning to fulfill the potential of this system. ...

journal_title：Current opinion in genetics & development

authors： Burke DT

更新日期：1991-06-01 00:00:00

abstract：:The detection of sequence variation with restriction fragment length polymorphisms is advancing our knowledge of plant genetics on several fronts. In the past year, there has been progress in genetic map construction, phylogeny studies, and the dissection of multigenic traits. In addition, new methods that are indepen...

journal_title：Current opinion in genetics & development

authors： Chang C,Meyerowitz EM

更新日期：1991-06-01 00:00:00